C3a 70-77

Research use only, not for human use.

C3a 70-77 is an octapeptide corresponding to the COOH terminus of C3a.

C3a 70-77 is an octapeptide corresponding to the COOH terminus of C3a.

The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10-7 M or higher and exceeds 75% at 10-6 M, irrespective of the stimulus. C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites.

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Complement 3a (70-77)

Immunology/Inflammation

Complement System

Complement system

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63555-63-5

823.94

C35H61N13O10

>98% (HPLC)

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CC(C)CC(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CO)NC(=O)C(C)N)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years